Latest research on Growth and Immune Factors contained in HP-100

The pituitary gland releases human growth hormone in quick spurts into the bloodstream at various times throughout the day. Once released into the bloodstream it remains active for only a few minutes, but long enough to stimulate its uptake into the liver. The liver must then convert the HGH into growth factors.

It is the growth factors that are directly responsible for most of the benefits associated with human growth hormone. The most important growth factor is called IGF-1 (insulin-like growth factor-1). IGF-1 is also known as somatomedin C. Another important growth factor is IGF-2, also known as somatomedin A. Research now suggests that there are many more growth factors in the body.

Growth factors are chemicals within the body that help to regulate the cell growth, cell repair, and cell replacement that is required to keep the body and metabolism functioning optimally. These same growth factors are also found in colostrum, milks and their derivatives such as whey. We now have the technology, like that used in the production of HP-100, to isolate the specific growth factors and make them biologically active after oral consumption.

IGF-1 & IGF-2

Insulin-like Growth Factor-1 & 2 are classed as a Mitogenic Growth Factor. They are Polypeptides that contain approximately 70 amino acids within its chemical structure (approximately 50% of its chemical structure is identical to that of Insulin).

Biological Functions and Therapeutic Benefits of IGF-1&2

Aging Process;
IGF is under investigation as a potential therapeutic agent for Dwarfism.
Children afflicted with Progeria (accelerated Aging) exhibit extremely low levels of IGF - this occurs as a result of Human Growth Hormone not triggering the endogenous manufacture of IGFs.

Cardiovascular System;
Exogenous, recombinant IGFs causes a reduction in afterload and causes positive contraction effects in Congestive Heart Failure patients.

Cells;
IGF stimulates the Growth of tissues by increasing the net NUMBER of Cells (compared to Human Growth Hormone which increases the SIZE of existing cells).

Metabolism;
IGF mobilizes Fatty Acids from Adipose Tissue for usage in the endogenous production of Energy (by preventing Insulin from transporting Glucose across Cell Membranes, the body is "forced" to mobilize Fatty Acids from Adipose Tissue as an alternative source of endogenous Energy).

IGFs are essential for normal Growth:
- IGFs binds weakly to the same Receptors within the body as Insulin (Insulin Receptors) and also binds to its own IGF Receptors located on the surfaces of cells.

IGFs are under investigation as a potential therapeutic agent in the treatment of Obesity (due its ability to mobilize Fatty Acids from Adipose Tissue in the endogenous production of Energy).

Musculoskeletal System;
Approximately 33% of Fibromyalgia patients exhibit low levels of IGF-1 (most likely as a result of insufficient release of human Growth Hormone). IGFs stimulates the production of Proteins in Muscle cells

IGFs increase Muscle Strength.
IGFs also enhance the function of Osteoblasts;
IGFs stimulate the production of Elastin in the Skin.

Nervous System;
IGF-1 is presently under investigation in the treatment of Amyotrophic Lateral Sclerosis (due to its ability to stimulate the growth of Muscle cells and to stimulate the growth of Neurons in the Brain).

Immunoglobulins: IgA, IgG, IgM

IgA is a type of Antibody (Immunoglobulin) that circulates in the Blood Plasma, Saliva and Mucous Membranes of the body - it comprises 20% of the total Antibody content of Blood Plasma.

IgG is a type of Antibody (Immunoglobulin) that is further sub-classified into IgG1, IgG2, IgG3 and IgG4. It comprises 75% of the total Antibody content of Blood Plasma in normal adults. IgG permeates the body's tissues during Inflammation and stimulates Phagocytes to engulf Antigens. It also helps to prevent recurrent Respiratory Tract Infections (patients with sub-optimal IgG levels generally experience recurrent Respiratory Tract Infections).

IgM is a type of Antibody (an Immunoglobulin) that is the largest of all of the Antibodies.
It comprises 5% of the total Antibody content of Blood Plasma.
IgM is a powerful activator of Complement (an endogenous Immune System Protein) that destroys Detrimental Bacteria that enter the bloodstream. It also helps to prevent recurrent Respiratory Tract Infections (patients with sub-optimal IgM levels generally experience recurrent Respiratory Tract Infections).

Fibroblast Growth Factor

Fibroblast Growth Factor stimulates the growth of Fibroblasts. It also stimulates the growth of Satellite Cells (specialised stem cells in Skeletal Muscle Fibers) that help in the repair and growth of muscle tissue. It also facilitates the healing of Wounds in skin.

Transforming Growth Factor

Transforming growth factor beta (TGF-ß) is a biological protein that comes in three isoforms called TGF-ß1, TGF-ß2 and TGF-ß3; it was also the original name for the founding member of this family that is now called TGF-ß1. The TGF-ß family is part of a superfamily of proteins known as the transforming growth factor beta superfamily, which includes inhibins, activin, anti-müllerian hormone, bone morphogenetic protein, decapentaplegic and Vg-1. TGF beta controls proliferation, differentiation, and other functions in most cell types. It can also act as a negative autocrine growth factor. One of the negative growth factors is TDF-8 (Myostatin). It has now been proven that blocking this TGF causes increases in muscle mass. One theory is that if we prevent Myostatin from becoming active by blocking its action and allow the positive TGF's to become more active instead, muscle growth will be accelerated. This could also be done by increasing the positive TGF levels so they dramatically out number the Myostatin protein and lesson the chances of it to become active because the positive TFG's have more chances to bind to the muscle receptors instead. Thus increasing muscle growth!

It is quite possible that the TGF's within HP-100 may have the effect of increasing the chances of the Myostatin protein not to become active. This desired effect could be achieved by consuming HP-100 3-4 times a day to maintain an influx of growth factors. This would in turn out number the Myostatin proteins and allow them a less chance to become active.

Note: HP-100 is safe to be used by all athletes and not banned by any sporting federation because the peptides isolated within the protein are all naturally occurring. Using it however does give you an unfair advantage over other athletes!

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