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One of the Best Supplements ever Developed!!
Discoveries with HUMANOFORT;
Thymosin is a family of naturally occurring peptides present in virtually all human and animal cells, with Thymosin Beta 4 (Tß4) being the most bio-active peptide. It is also found in the product Humanofort, which is sequenced in embryonic development and contained in the extract matrix of the humanofort material. It is a protein peptide that diminishes with cell age, in which restoration of levels rejuvenates the cell to function back to an optimum level as seen in a young matured cell, preventing cell death.
* Endothelial (blood vessels) cell differentiation (related to
increasing red blood cells)
It helps optimise and restore cell function therefore increasing cell signalling which in turn makes the body more efficient at producing the chemical actions it needs to sustain regeneration and energy needs.
One of Tß4 key mechanisms of action is its ability to regulate the cell-building protein, Actin, a vital component of cell structure and movement. Of the thousands of proteins present in cells, actin represents up to 10% of the total proteins which therefore plays a major role in the genetic makeup of the cell.
This potent peptide is a member of a ubiquitous family of 16 related molecules with a high conservation of sequence and localization in most tissues and circulating cells in the body. Tß4 not only binds to actin, but also blocks actin polymerization and is the actin-sequestering molecule in eukaryotic cells.
Tß4 was identified as a gene that was up-regulated four-to-six fold during early blood vessel formation and found to promote the growth of new blood cells from the existing vessels. This peptide is present in wound fluid and when administered, it promotes wound healing, muscle building and speeds up recovery time of muscles fibres and their cells. It also increases endurance and strength of muscle fibres making them function more efficiently, reducing lactic acid build up and fatigue, enabling the muscle to continually contract without becoming tired.
An additional key factor of Tß4 is that it promotes cell migration through a specific interaction with actin in the cell cytoskeleton. It has been demonstrated that a central small amino acid long-actin binding domain has both blood cell reproduction and wound healing characteristics. These characteristics are uncovered by accelerating the migration of endothelial cells and keratinocytes. It also increases the production of extracellular matrix-degrading enzymes.
Research confirms that Tß4 is a potent, naturally occurring wound repair factor with anti-inflammatory properties. Tß4 is different from other repair factors, such as growth factors, in that it promotes endothelial and keratinocyte migration. It also does not bind to the extracellular matrix and has a very low molecular weight meaning it can travel relatively long distances through tissues.
FOLLISTATIN
Another Peptide of importance in Humanofort is the discovery of Follistatin. In a research study published in the Journal of the American College of Nutrition October 2006, Volume 25, Number 5, Abstract 66, the 'Absorption profile and hormonal influences of fertile egg yolk ingestion in the human' was analysed.
A male subject was chosen because the normal baseline male physiology does not contain any measurable concentration of follistatin. Fertile egg yolk powder properly processed to preserve active follistatin was obtained. After initial blood draw and subsequent oral dose of the egg powder extract, serum follistatin levels were qualitatively and quantitatively measured as an indication of absorption.
In addition, since we know follistatin is a negative modulator of Myostatin, a muscle growth blocking protein, serum myostatin levels were also qualitatively and quantitatively measured as an indicator of hormonal influence and thus true pharmacokinetic activity.
Testing utilised a purchased follistatin and myostatin standard for verification. Confirmations were run by ELISA and quantitation’s by Liquid Chromatography Tandem Mass Spectrometer with third degree fragmentation.
Results showed a predicted zero level of follistatin at baseline with a myostatin level of 46pg/ml. 12 hours after dosing of the egg powder extract, serum follistatin increased to 57.1pg/ml while myostatin levels dropped to 34pg/ml. 24 hours after initial dosing, measurements were taken again, in which follistatin levels began to predictably drop to 11.4pg/ml. Yet myostatin levels continued to drop down to 31pg/ml.
These results clearly indicated that a fertile egg yolk powder properly processed to preserve active follistatin, as in the Humanofort Extract, when orally ingested, results in detectable serum follistatin levels as well as having significant pharmaco-kinetic activity as shown by the hormonal down-regulation of serum myostatin.
In theory, continued ingestion of the Humanofort extract would result in substained down-regulation of serum myostatin levels, allowing genetic pathways which involve Insulin Growth Factors such as IGF-1 to exert their effect on stem cells and increase the rate of new muscle tissue repair and development.
AN AMAZING PRODUCT!
Humanofort not only supplies peptides involved in muscular regeneration and development, which is also a part of any anti-aging strategy (we lose muscle tissue as we age), it also supplies peptides involved in regeneration and development of all other tissues that make up your body as well. In addition, there are also special peptides such as Thymosins that ensure proper DNA encoding so your cells function at their optimum, preventing genetic flaws causing cell death and mutations. Further more, Humanofort may also help elevate hormone levels that normally decrease with age, as well as hormones associated with increasing sports performance. Check out the Research Study below;
HUMANOFORT study with RUGBY Players
The effects of oral administrated Humanofort on steroid hormone levels of trained rugby players.
I - Research and Production Laboratory “Hipocrate”, Bucharest, str. Prahova nr.6 78400 Bucharest sect.1 2 - Institute of Endocrinology, Bucharest str. Fundeni nr. 43 74323 Bucharest sect. 3 3- ‘Ion Cantacuzino” Institute, Bucharest Splaiul Independenpei nr.97 75342 Bucharest sect. 6 4 - Medicine and Pharmacy University “Carol Davila” Bucharest Bd. Eroilor nr.42 72540 Bucharest sect.6
Human subjects and experimental procedure: 28 healthy male volunteers (rugby players, ages 20-32) were separated into three experimental groups - 8 persons in control (placebo) group, 10 persons in the group receiving 6 capsules of Humanofort daily and 10 persons in a group receiving 12 capsules of Humanofort daily. In treated groups each patient received 2 (or 4) capsules of Humanofort three times per day, 1 hour before meals. In control group (placebo), patient received 2 capsules filled with standard egg powder mixed with similar amounts of additives (fillers, preservatives, anti-cakers, intestinal absorption enhancers, lubricants) as used in Humanofort preparation. The product / placebo was administered for three weeks. The subjects continued their normal training and had not received steroid preparations for at least two months prior to the Humanofort treatment.
Serum samples analysis: Serum samples, taken before and after treatment, were assayed for steroid hormones. In order to establish baseline values for steroid hormones, samples taken just a day earlier to the first dose, were assayed. Samples taken on day 21 were used in the assays for comparison, and expressed as a percentage of baseline. In this way, the circulating levels of various steroids were determined for each patient at the beginning and at the end of the treatment in order to assess the effect of Humanofort administration. Assays were performed using commercial kits according to each manufacturer’s instructions: Nichols Institute Diagnostics, USA (DHEA, DHEAS); Diagnostics Systems Laboratories, USA (androstenedione, testosterone).
RESULTS AND DISCUSSIONS The influences of Humanofort administration on steroid hormones are presented in table.1. The results clearly show that, in healthy male volunteers, oral administration of Humanofort results in significantly elevated levels of DHEAS and androstenedione. The testosterone level is slightly increased, at the limit of statistical significance.
Table. 1 - Influence of oral administration of Humanofort on the
serum steroid levels
As seen in the table. 1, exercise alone (Placebo) increased levels of steroid hormones from baseline. With the addition of Humanofort, steriod hormone levels are significantly increased with 6 capsules a day providing the best average increase in all steriod hormones tested.
CONCLUSION Supplementing 6 capsules of Humanofort a day for 21 days can significantly elevate steroid hormone levels in trained athletes. Elevated steroid hormone levels are associated with performance enhancement, increased protein synthesis and muscle hypertrophy.
If supplementing with other ASN NANO Technology products such as NANO Creatine, HP100, NANOBOLIC, HPC, Tribestanol, Xteme PUMP or Xtreme Blast, only 3 capsules a day is needed in which a serving suggestion would be 1 capsule in the morning and 2 capsules just before you go to bed.
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